A cell-permeable phenoxyacrylamido compound that inhibits hypoxia-induced cellular HIF-1alpha accumulation in a manner similar to LW6 by upregulating Hippel-Lindau tumor suppressor gene product pVHL, but with much higher potency (IC50 = 120nM vs 2.44uM, respectively, against hypoxia-induced HRE reporter activity in HCT116 cells). Shown to suppress HIF-1 target genes expression in HCT116 cultures and inhibit HUVEC tubule formation (effective conc. 2uM) under hypoxia conditions. Molar Mass: 530.7 Solubility: DMSO Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight:
530.7
Purity:
~99% (HPLC)
Form:
Supplied as a white powder.
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