Histone Lysine Demethylase Inhibitor VII, GSK-J1 (3-(6-(4,5-Dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-ylamino)propanoic Acid, JHDM Inhibitor II), CAS [[1373422-53-7]]

Product Overview

• Article Name: Histone Lysine Demethylase Inhibitor VII, GSK-J1 (3-(6-(4,5-Dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-ylamino)propanoic Acid, JHDM Inhibitor II), CAS [[1373422-53-7]]
• Biozol Catalog Number: USB-217430
• Supplier Catalog Number: 217430
• Alternative Catalog Number: USB-217430-10
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A pyridinyl-pyrimidinylaminopropanoic acid that effectively inhibits KDM6 family H3K27m3 demethylases JMJD3 and UTX (IC50 = 18 and 56uM, respectively, by MALDI Mass detection) in an alpha-ketoglutarate-competitive, peptide substrate-non-competitive manner, displaying much reduced potency against JARID1C, JMJD1a, JMJD2a, JMJD2c, JMJD2d, JMJD2e, as well as112 kinases and 60 non-kinase enzymes. Recommended for cell-free assays only. For culture treatment, use the cell-permeable pro-drug GSK-J4. CAS Number: 1373422-53-7 Primary Target: H3K27me3 demethylases JMJD3 & UTX Molar Mass: 389.5 Solubility: DMSO Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 389.5
• Purity: 98% (HPLC)
• Form: Supplied as a light yellow powder.
• CAS Number: [1373422-53-7]