A cell-permeable triazolo-farnesylthiopropanoate compound that acts as a potent, reversible, and isoprenyl mimetic competitive inhibitor of isoprenylcysteine carboxyl methyltransferase activity (ICMT, IC50=800nM, Ki=400nM). Shown to prevent K-Ras membrane localization in GFP-K-Ras transfected Jurkat T-cells. Exhibits selective toxicity towards wt-Icmt+/+ mouse embryonic fibroblasts (MEFs) over Icmt-/- MEFs (IC50=33 and >100uM). Also shown to arrest the proliferation of PaTu-8902, a highly metastatic pancreatic cancer cells (IC50=8uM). Synonyms: (E)-methyl-3-((5-(4-(2-((1,1-biphenyl]-4-yl)ethyl)-1H-1,2,3-triazol-1-yl)-3-methylpent-2-en-1-yl)thio)propanoate CAS No: 1350561-58-8 Molecular Formula: C26H31N3O2S Molecular Weight: 449.6 Solubility: DMSO (50mg/ml) Purity: 98% (HPLC) Appearance: White solid Storage and Stability: Store at -20C under inert atmosphere. Stable for 6 months after receipt.
Molecular Weight:
449.6
CAS Number:
[1350561-58-8]
* VAT and and shipping costs not included. Errors and price changes excepted
