iPSC Induction Enhancer II, OAC1 N-(1H-Pyrrolo[2,3-c]pyridin-5-yl)benzamide, Induced Pluripotent Stem Cells Induction Enhancer II, Oct4-Activating Compound 1), CAS [[300586-90-7]]
Biozol Catalog Number:
USB-217463
Supplier Catalog Number:
217463
Alternative Catalog Number:
USB-217463-25
Manufacturer:
US Biological
Category:
Biochemikalien
A cell-permeable pyrrolopyridinyl-benzamide compound that is reported to enhance the efficiency of 4F/4TF-induced iPSC generation from MEFs cultured in either feeder cell-containing ESC media or in feeder-/serum-free iSF1 media (1uM OAC1 treatment starts 48h after viral transduction). OCA1 is shown to increase cellular Oct4, Nanog, Sox2, and Tet1 mRNA levels via a yet unidentified mechanism, although OAC1 is reported not affect Oct4 promoter methylation, cellular Wnt signaling, or p53 and p21 mRNA levels. Six other iPSC reprogramming improving reagents, AM580, AzaC, BIX-01294, Tranylcypromine, VPA, and Vitamin C, in comparison, do not exhibit Oct4 and Nanog promoters enhancing activity, while BIO is demonstrated to be 3.8- and 6-fold less potent than OAC1, respectively, in inducing Oct4 and Nanog transcription. Synonyms: Induced Pluripotent Stem Cells Induction Enhancer II, Oct4-Activating Compound 1, N-(1H-Pyrrolo[2,3-c]pyridin-5-yl)benzamide CAS No: 300586-90-7 Molecular Formula: C14H11N3O Molecular Weight: 237.3 Solubility: DMSO Molar Mass: 237.3 Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight:
237.3
Purity:
99% (HPLC)
Form:
Supplied as an off-white solid.
CAS Number:
[300586-90-7]
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