IRE1 Inhibitor I, STF-083010 (N-[(2-Hydroxynaphthalen-1-yl)methylidene]thiophene-2-sulfonamide, N-[(2-Hydroxy-1-naphthyl)methylene]-2-thiophenesulfonamide, ER-to-Nucleus Signaling 1 Inhibitor I, ERN1 Inhibitor I, Inositol-Reguirin

Product Overview

• Article Name: IRE1 Inhibitor I, STF-083010 (N-[(2-Hydroxynaphthalen-1-yl)methylidene]thiophene-2-sulfonamide, N-[(2-Hydroxy-1-naphthyl)methylene]-2-thiophenesulfonamide, ER-to-Nucleus Signaling 1 Inhibitor I, ERN1 Inhibitor I, Inositol-Reguirin
• Biozol Catalog Number: USB-217465
• Supplier Catalog Number: 217465
• Alternative Catalog Number: USB-217465-10
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A cell-permeable salicylidene compound that is shown to directly target Irea1 and disrupt Ire1-XBP1 (X-box binding protein) unfolded protein response (UPR) pathway in RPMI8226 multiple myeloma (MM) cells. Selectively inhibits ER stress-initiated endonuclease activity of Ire1 and blocks XPB1 mRNA splicing in MM cells at 60uM and XBP1 activity in transgenic XBP1-luc mice (bortezomib 1mg/kg and 60mg/kg of STF-083010, i.p.). Displays preferential cytotoxicity towards CD138+ cells over B, T and NK cells and antitumor properties. Formula: C15H11NO3S2 Molecular Weight: 317.4 Solubility: DMSO (100mg/ml clear, yellow solution) Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 317.4
• Purity: ~98% (HPLC)
• Form: Supplied as a yellow powder.