JAK Inhibitor I (P6, DBI, (2-(1,1-Dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, Pyridone 6, JAK1 Inhibitor I, JAK3 Inhibitor VII, JAK2 Inhibitor I), CAS [[457081-03-7]]

Product Overview

• Article Name: JAK Inhibitor I (P6, DBI, (2-(1,1-Dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, Pyridone 6, JAK1 Inhibitor I, JAK3 Inhibitor VII, JAK2 Inhibitor I), CAS [[457081-03-7]]
• Biozol Catalog Number: USB-217473
• Supplier Catalog Number: 217473
• Alternative Catalog Number: USB-217473-500,USB-217473-1
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A potent, reversible, cell-permeable, and ATP-competitive inhibitor of Janus protein tyrosine kinases (JAKs). Displays potent inhibitory activity against JAK1 (IC50=15nM for murine JAK1), JAK2 (IC50=1nM), JAK3 (Ki=5nM), and Tyk2 (IC50=1nM). Inhibits other kinases at much higher concentrations. Shown to inhibit IL2- and IL4-dependent proliferation of CTLL cells and block the phosphorylation of STAT5, and further induce growth inhibition of multiple myeloma cells expressing activated JAKs and STAT3, unlike AG 490. A 10mM solution of JAK Inhibitor I in DMSO is also available. CAS No: 457081-03-7 Formula: C18H16FN3O Primary Target: Murine JAK1 Primary Target IC50: 15nM Secondary Target: JAK2 (IC50 = 1nM), JAK3 (Ki = 5nM), Tyk2 (IC50 = 1nM) Solubility: DMSO Molecular Weight: 309.3 Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 309.3
• Purity: 98% (HPLC)
• Form: Supplied as a off-white solid.
• CAS Number: [457081-03-7]