JAK3/GSK-3b/PKCa Inhibitor (3-(5-(4-(2-Hydroxy-2-methyl-propionyl)-piperazin-1-yl)-2-trifluoromethyl-phenyl)-4-(1H-indol-3-yl)-pyrrole-2,5-dione, NIBR3049, JAK3 Inhibitor XII), CAS [[1260181-14-3]]

Product Overview

• Article Name: JAK3/GSK-3b/PKCa Inhibitor (3-(5-(4-(2-Hydroxy-2-methyl-propionyl)-piperazin-1-yl)-2-trifluoromethyl-phenyl)-4-(1H-indol-3-yl)-pyrrole-2,5-dione, NIBR3049, JAK3 Inhibitor XII), CAS [[1260181-14-3]]
• Biozol Catalog Number: USB-217481
• Supplier Catalog Number: 217481
• Alternative Catalog Number: USB-217481-5
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A cell-permeable phenyl-indolyl maleimide compound that acts as a potent, ATP-binding site targeting and reversible inhibitor of GSK-3b, JAK3, PKCa and PKCth (IC50=3, 8, 13 and 68nM, respectively) with excellent selectivity over 40-kinases, including JAK1, JAK2 and Tyk2 (IC50=1.017, 2.55 and 8.055uM, respectively). Shown to efficiently block interleukin stimulated STAT5 phosphorylation and T cell costimulation (IC50=0.525, 1.294 and 0.689uM in IL15-MO7, IL2-CTLL and TCR/CD28-Jurkat cells, respectively). Synonyms: 3-(5-(4-(2-Hydroxy-2-methyl-propionyl)-piperazin-1-yl)-2-trifluoromethyl-phenyl)-4-(1H-indol-3-yl)-pyrrole-2,5-dione, NIBR3049, JAK3 Inhibitor XII CAS No: 1260181-14-3 Molecular Formula: C27H25F3N4O4 Molecular Weight: 526.5 Solubility: DMSO Storage and Stability: Store at -20C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Product Properties

• Molecular Weight: 526.5
• Purity: 95% (HPLC)
• Form: Supplied as a yellow solid.
• CAS Number: [1260181-14-3]