JMJD Histone Demethylase Inhibitor III ((E)-4-(Hydroxy(4-(4-((naphthalen-1-ylcarbamoyloxy)methyl)benzylamino)butyl)amino)-4-oxobut-2-enoic Acid), CAS [[1310809-17-6]]

Product Overview

• Article Name: JMJD Histone Demethylase Inhibitor III ((E)-4-(Hydroxy(4-(4-((naphthalen-1-ylcarbamoyloxy)methyl)benzylamino)butyl)amino)-4-oxobut-2-enoic Acid), CAS [[1310809-17-6]]
• Biozol Catalog Number: USB-217482
• Supplier Catalog Number: 217482
• Alternative Catalog Number: USB-217482-5
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A substrate (methyl lysine) and cofactor (a-ketoglutarate) mimicking bivalent benzylamino-butylamino-N-hydroxybutenoic acid compound that acts as a selective in vitro inhibitor of Jumonji domain-containing histone demethylases (JHDMs, IC50=4.3, 3.4, 5.9, 10 and 43uM for JMJD2A, JMJD2C, JMJD2E, PHF8 and JMJD3, respectively) over LSD1, asparaginyl and prolyl hydroxylases, and histone deacetylases (IC50=54, 83, 31, 22, 620, 680 and >800uM for PHD1, PHD2, PHD3, FIH, LSD1 and HDACs, respectively). The cellular active JHDM Inhibitor, Methylstat is also available. Formula: C27H29N3O6 Solubility: DMSO Molecular Weight: 491.5 Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 491.5
• Purity: ~95% (HPLC)
• Form: Supplied as an off-white powder.
• CAS Number: [1310809-17-6]