JMJD Histone Demethylase Inhibitor IV, Methylstat ((E)-Methyl-4-(hydroxy(4-((4-(((naphthalen-1-ylcarbamoyl)oxy)methyl)benzyl)amino)butyl)amino)-4-oxobut-2-enoate, Histone Lysine Demethylase Inhibitor VII, Methylstat), CAS [[131087

Product Overview

• Article Name: JMJD Histone Demethylase Inhibitor IV, Methylstat ((E)-Methyl-4-(hydroxy(4-((4-(((naphthalen-1-ylcarbamoyl)oxy)methyl)benzyl)amino)butyl)amino)-4-oxobut-2-enoate, Histone Lysine Demethylase Inhibitor VII, Methylstat), CAS [[131087
• Biozol Catalog Number: USB-217483
• Supplier Catalog Number: 217483
• Alternative Catalog Number: USB-217483-10
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A methyl ester prodrug of in vitro active N-hydroxybutenoic acid compound that is shown to preferentially induce hypermethylation of histone proteins (EC50 for H3K4me3 and H3K9me3=10.3 and 8.6uM in KYSE150 cells, and 6.7 and 6.3uM in MCF7 cells, respectively), and arrests cell growth. Acts as a selective inhibitor of Jumonji domain-containing histone demethylases (JHDMs) over prolyl hydroxylases (PHDs), and prevents myogenesis through inhibition of H3K27 demethylase UTX in C2C12 cells at 2uM. CAS No: 1310877-95-2 Formula: C28H31N3O6 Solubility: DMSO Molecular Weight: 505.6 Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 505.6
• Purity: 96% (HPLC)
• Form: Supplied as an off-white powder.
• CAS Number: [1310877-95-2]