Leukadherin-1 (aMb2 Agonist II, CD11b Agonist II, LA1, Mac-1 Agonist II, CR3 Agonist II, CD11b/CD18 Agonist, 4-(5-((3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl)furan-2-yl)-benzoic Acid), CAS [[344897-95-6]]

Product Overview

• Article Name: Leukadherin-1 (aMb2 Agonist II, CD11b Agonist II, LA1, Mac-1 Agonist II, CR3 Agonist II, CD11b/CD18 Agonist, 4-(5-((3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl)furan-2-yl)-benzoic Acid), CAS [[344897-95-6]]
• Biozol Catalog Number: USB-217511
• Supplier Catalog Number: 217511
• Alternative Catalog Number: USB-217511-25
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A furanyl thiazolidinone compound that binds CD11b aA/aI domain in a reversible manner and stabilizes aA in a high-affinity binding conformation toward known CD11b/CD18 (aMB2, CR3, Mac-1) ligands, fibrinogen, ICAM-1, and iC3B. Reported to be superior to IMB-10 in enhancing Mac-1-mediated cell adhesion (EC50=4 vs. >50uM on fibrinogen surface). Effectively suppresses leukocyte recruitment in various inflammatory disease models involving mice, rats, and zebrafish embryos in vivo. CAS No: 344897-95-6 Formula: C22H15NO4S2 Molecular Weight: 421.5 Solubility: DMSO Storage and Stability: Store at -20C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Product Properties

• Molecular Weight: 421.5
• Purity: 95% (HPLC)
• Form: Supplied as a red-brown solid.
• CAS Number: [344897-95-6]