LSD1 Inhibitor IV, RN-1,HCl (2-(1R,2S)-2-(4-(Benzyloxy)phenyl)cyclopropylamino)-1-(4-methylpiperazin-1-yl)ethanone, HCl, Lysine (K)-Specific Demethylase Inhibitor IV,RN-1,HCl, BHC110 Inhibitor IV, KDM1 Inhibitor IV, MOA Inhibitor

Product Overview

• Article Name: LSD1 Inhibitor IV, RN-1,HCl (2-(1R,2S)-2-(4-(Benzyloxy)phenyl)cyclopropylamino)-1-(4-methylpiperazin-1-yl)ethanone, HCl, Lysine (K)-Specific Demethylase Inhibitor IV,RN-1,HCl, BHC110 Inhibitor IV, KDM1 Inhibitor IV, MOA Inhibitor
• Biozol Catalog Number: USB-217521
• Supplier Catalog Number: 217521
• Alternative Catalog Number: USB-217521-10
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A cell-permeable tranylcypromine (parnate) analog that acts as a potent, irreversible inhibitor of lysine specific demethylase 1 (LSD1, IC50=70nM in a HRP-coupled assay using H3K4Me2 peptide substrate). Forms a covalent adduct with flavin adenine dinucleotide (FAD). Shown to cross the blood brain barrier. Exhibits moderate selectivity over amine oxidases MAO-A and MAO-B (IC50 =0.51 and 2.785uM, respectively). Displays desirable pharmacokinetic properties (brain/plasma exposure ratio of 88.9), and impairs long-term memory without affecting short-term memory in mice (10mg/kg, i.p.). Molecular Formula: C23H29N3O22HCl Solubility: DMSO or H2O Molecular Weight: 416 Storage and Stability: Store at -20C under inert atmosphere. Protect from light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Product Properties

• Molecular Weight: 416
• Purity: 97% (HPLC)
• Form: Supplied as a yellow solid.