MARK/Par-1 Activity Inhibitor, 39621 (N-(2,5-Dimethylphenyl)-2-(4-(4-methoxyphenyl)-3-oxo-3,4-dihydropyrazin-2-ylthio)acetamide, Microtubule Affinity Regulating Kinase Inhibitor, MAP Affinity Regulating Kinase Inhibitor, PAR1 Inhi

Product Overview

• Article Name: MARK/Par-1 Activity Inhibitor, 39621 (N-(2,5-Dimethylphenyl)-2-(4-(4-methoxyphenyl)-3-oxo-3,4-dihydropyrazin-2-ylthio)acetamide, Microtubule Affinity Regulating Kinase Inhibitor, MAP Affinity Regulating Kinase Inhibitor, PAR1 Inhi
• Biozol Catalog Number: USB-217532
• Supplier Catalog Number: 217532
• Alternative Catalog Number: USB-217532-10
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A cell-permeable dihydropyrazinyl-thioacetamide that acts as an ATP-competitive MARK-selective inhibitor (IC50=3.6uM, [ATP]=100uM). Shown to effectively block primary rat cortical neuron axon growth (5.7um/hr vs 32.5um/hr with or without 20uM inhibitor) and prevent MARK2 overexpression-induced Tau Ser262 phosphorylation and cytotoxicity in CHO cells (10uM). Formula: C21H21N3O3S Molecular Weight: 395.5 Solubility: DMSO (100mg/ml clear, yellow solution) Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 395.5
• Purity: ~98% (HPLC)
• Form: Supplied as a beige solid.