A cell-permeable fluorinated N,N-dialkylaminostilbene (FIDAS) analogue of FIDAS-3 that competes against SAM for MAT2A binding and is >2-fold more potent than FIDAS-3 in inhibiting MAT2A-catalyzed SAM synthesis both in cell-free assays (IC50 = 2.1uM) and in LS174T colorectal cancer (CRC) cultures (3uM). FIDAS-5 at 3uM is shown to completely inhibit the proliferation of LS174T for up to 7 d in vitro and effectively suppress HT29 CRC tumor expansion in mice in vivo (20mg/kg/day p.o.). Synonyms: FIDAS5, Methionine S-Adenosyltransferase 2A Inhibitor II, (E)-4-(2-Chloro-6-fluorostyryl)-N-methylaniline Molecular Formula: C15H13CIFN Molecular Weight: 261.73 Purity: 97% (HPLC) Appearance: Yellow semi-solid Solubility: DMSO (100mg/ml) Primary Target: MAT2A NMR: Conforms to structure LC-MS: Conforms to structure Elemental Analysis: As Reported Storage and Stability: May be stored at 4C. Stable for 6 months after receipt. Reconstitute with DMSO. Aliquot and store at -20C. Stable for 3 months. Hygroscopic and light sensitive. Store under inert gas.
Molecular Weight:
263.53
Purity:
97% (HPLC)
Form:
Yellow semi-solid
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