An antagonist of the 5-HT2B (pki = 8.0-9.4) and 5-HT2C (pki = 8.6-9.1) receptor. At the 5-HT1A and some other 5-HT receptors it serves as a partial agonist. It is known to have partial agonist effects on other 5-HT receptors as well. In neuronal and platelet culture, Methysergide blocks serotonin action with an IC50 = 18uM. Originally developed in the 1960's as a migraine/cluster headache treatment, but discontinued due to significant physiological and pyschotropic side effects. Methysergide is still actively used in research as a 5-HT2 receptor antagonist in both in vivo and in vitro experiments. CAS Number: 129-49-7 Molecular Formula: C21H27N3O2C4H4O4 Solubility: H2O Primary Target: 5-HT Molecular Weight: 469.54 Appearance: Supplied as an off-white solid. Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight:
469.54
Purity:
99% (HPLC)
Form:
Supplied as an off-white solid.
CAS Number:
[129-49-7]
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