MMP-2 Inhibitor IV (Bone Resorption Inhibitor, (4-chlorobiphenyl-4ylsulfonamido)methylenediphosphonic Acid)
Biozol Catalog Number:
USB-217560
Supplier Catalog Number:
217560
Alternative Catalog Number:
USB-217560-10
Manufacturer:
US Biological
Category:
Biochemikalien
A cell-permeable, bisphosphonate derivative that displays nanomolar activity against MMP-2 (IC50=37nM), with good selectivity over MMP-8 (320nM), MMP-9 (>1uM), and MMP-14 (> 1uM). It is shown to inhibit osteoclast activity in a macrophage cell line, J774 (IC50=1.7uM), which is more potent compared with other bisphosphonates such as Alendronate, (IC50=30uM), and Zolendronate (7.8uM), without observable cytotoxicity in HepG2 cells. At 25uM, it abolishes the formation of actin rings, which are functional structures that are typical of resorbing osteoclasts, at activity levels comparable with those of zolendronic acid, inhibits bone resportion in vitro, and demonstrates cytotoxic properties in murine osteoclasts. Chemical Formula: C13H14ClNO8P2S Solubility: DMSO Molecular Weight: 441.72 Storage and Stability: Store at 4C. Caution: Light-sensitive. Following reconstitution, aliquot and freeze at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
441.72
Purity:
99% (HPLC)
Form:
Supplied as an off-white powder.
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