MNK1/2 Inhibitor II, ETP-45835 (ETP45835 MNK Inhibitor II, Mitogen-Activated Protein Kinase-Interacting Kinase Inhibitor II) (4-(3-(Piperidin-4-yl)-1H-pyrazol-5-yl)pyridine, diHCl)

Product Overview

• Article Name: MNK1/2 Inhibitor II, ETP-45835 (ETP45835 MNK Inhibitor II, Mitogen-Activated Protein Kinase-Interacting Kinase Inhibitor II) (4-(3-(Piperidin-4-yl)-1H-pyrazol-5-yl)pyridine, diHCl)
• Biozol Catalog Number: USB-217563
• Supplier Catalog Number: 217563
• Alternative Catalog Number: USB-217563-10
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A cell-permeable 3,5-disubstituted pyrazolo compound that acts as a selective MNK inhibitor (IC50=646 and 575nM, respectively, against MNK1 and MNK2) with much reduced or little activity against 24 other kinases (<15% inhibition at 5uM). Reported to exhibit good aqueous solubility (>100uM at pH 7.4) and inhibit the proliferation (IC50=17uM) and cellular eIF4E Ser209 phosphorylation (IC50=4.7uM) of MV4:11 cells. Molecular Formula: C13H16N42HCl Solubility: H2O Molecular Weight: 301.2 Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 301.2
• Purity: 98% (HPLC)
• Form: Supplied as a white solid.