Nebivolol Hydrochloride (rel-(aR,aR,2R,2S)-a,a-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] Hydrochloride, b1-Adrenoceptor Antagonist, Nebivolol Hydrochloride, Nebilet, R-65824, Narbivolol), CAS [[1525

Product Overview

• Article Name: Nebivolol Hydrochloride (rel-(aR,aR,2R,2S)-a,a-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] Hydrochloride, b1-Adrenoceptor Antagonist, Nebivolol Hydrochloride, Nebilet, R-65824, Narbivolol), CAS [[1525
• Biozol Catalog Number: USB-217580
• Supplier Catalog Number: 217580
• Alternative Catalog Number: USB-217580-10
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A competitive, highly selective beta-1-adrenoceptor antagonist (more than 40-fold selective for beta-1 than beta-2, Ki1 and beta-2, respectively). The most beta-1-selective chemical of the beta-blockers tested so far. Used for treatment of essential hypertension and highly cardioselective. Induces mild vasodialation via a nitric oxide- and cGMP-depedent pathways (EC50 = 11.36uM in renal arteries). CAS Number: 152520-56-4 Formula: C22H25F2NO4 HCl Solubility: DMSO Primary Target: 1-adrenoceptor Primary Target Ki: 0.88 and 44 for 1 and 2, respectively Molar Mass: 441.9 Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 441.9
• Purity: ~98% (HPLC)
• Form: Supplied as a white powder.
• CAS Number: [152520-56-4]