Methysticin has been identified from kava to have potent NF-kB inhibitory activity and minimum toxicity. It is shown to inhibit NF-kB (IC50 = 0.19ug/ml) 100 times more potently than traditional kava in A549 cells in an in vitro luciferase-based assay. It is also reported to suppress the elevation of IKKalpha, p65, and COX-2 and the degradation of IkBalpha in A549 cultures stimulated with TNF-alpha, through Western Blot analysis. Synonyms: (6R)-6-[(1E)-2-(1,3-Benzodioxol-5-yl)ethenyl]-5,6- dihydro-4- methoxy-2H-pyran-2-one CAS No: 495-85-2 Molecular Formula: C15H14O5 Molar Mass: 274.27 Solubility: DMSO Purity: 97% Storage and Stability: Store at -20C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
274.27
CAS Number:
[495-85-2]
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