NS 1738 is a positive allosteric modulator of the alpha7-containing neuronal nicotinic acetylcholine receptors (nAChRs). When applied in the presence of ACh, NS 1738 increases the peak amplitude of the current flowing through alpha7-containing nAChRs (EC50 = 3.4 µM). NS 1738 displays no substantial activity for alpha4beta2-, alpha3beta3-, and alpha1-containing receptors. It is modestly brain-penetrant and counteracts (-)-scopolamine-induced deficit in acquisition of a water-maze learning task in rats. NS 1738 also improves performance in the rat social recognition test.1 NS 1738 is used to selectively evaluate the role of alpha7-containing nAChRs in signaling pathways. Synonyms: N-(5-chloro-2-hydroxyphenyl)-N-[2-chloro-5-(trifluoromethyl)phenyl]-urea CAS No: 501684-93-1 Molecular Formula: C14H9Cl2F3N2O2 Molecular Weight: 365.1 Solubility: DMSO, DMF, Ethanol Purity: 98% Form: Supplied as a crystalline solid Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight:
365.1
CAS Number:
[501684-93-1]
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