PDE4D Inhibitor, GEBR-7b ((E)-3-(cyclopentyloxy)-4-methoxybenzaldehyde, O-2-(2,6-dimethylmorpholino)-2-oxoethyl oxime, GEBR-7b), CAS [[1349848-90-3]]

Product Overview

• Article Name: PDE4D Inhibitor, GEBR-7b ((E)-3-(cyclopentyloxy)-4-methoxybenzaldehyde, O-2-(2,6-dimethylmorpholino)-2-oxoethyl oxime, GEBR-7b), CAS [[1349848-90-3]]
• Biozol Catalog Number: USB-217632
• Supplier Catalog Number: 217632
• Alternative Catalog Number: USB-217632-5
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A cell permeable, potent, and selective oxime PDE4D inhibitor (IC50=0.67uM) which displays much reduced activities toward other PDE4 isoforms. It is shown to cause a significant 40% increase in extracellular cAMP in the hippocampus of freely moving rats in vivo at 100uM, but has no effect on Ab levels. This compound elicits cognitive enhancement in vivo at the optimum dose of 0.003mg/kg in both mice and rat models, and unlike rolipram, does not cause emesis-like behavior in rodents. Synonyms: GEBR-7b, (E)-3-(cyclopentyloxy)-4-methoxybenzaldehyde, O-2-(2,6-dimethylmorpholino)-2-oxoethyl oxime CAS No: 1349848-90-3 Molecular Formula: C21H30N2O5 Molecular Weight: 390.5 Solubility: DMSO (100mg/ml, clear, colorless solution) Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 390.5
• Purity: 95% (HPLC)
• Form: Supplied as a pale yellow semi-solid.
• CAS Number: [1349848-90-3]