An isoquinoline carboxamide that acts as a potent ligand for peripheral bezodiazepine receptor (Kd = 20nM). Exhibits anti-inflammatory properties. Binds to monocytes and following lesioning its binding up-regulated in brain macrophages and activated microglia. Shown to enhance the susceptibility of cells to apoptosis induction by DNA damaging agents and can reverse the suppression of apoptosis by Bcl-2. Serves as a ligand of the outer membrane translocator protein and reduces mitochondrial transmembrane potential within 30 minutes of exposure (~100uM). CAS Number: 85532-75-8 Synonyms: TSPO Activator II, Mitochondrial Translocator Protein Activator II, PK 11195, PK-11195, PK11195 Molecular Formula: C21H21ClN2O Solubility: DMSO Primary Target: peripheral bezodiazepine receptor Primary Target Ki: 20nM Molecular Weight: 352.86 Appearance: Supplied as a white solid. Purity: 98% (HPLC) Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight:
352.86
Purity:
98% (HPLC)
Form:
Supplied as a white solid.
CAS Number:
[85532-75-8]
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