Heat-stable protein kinase inhibitor (PKI) peptide sequence (14-22) that has been myristoylated at the N-terminus, enhancing its cell-permeability. The non-myristoylated version of this peptide is a highly specific inhibitor (Ki=6nM) of cAMP-dependent protein kinase. Synonyms: PKI 14-22 Amide, Cell-Permeable, Myr-GRTGRRNAI-NH2, Myristoylated Protein Kinase A Inhibitor Amide 14-22, Cell-Permeable, Protein Kinase A Inhibitor 14-22 Amide, PKA Inhibitor XIII Formula: C53H100N20O12 Sequence: Myr-N-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2 Primary Target: cAMP-dependent protein kinase Primary Target Ki: 36nM Solubility: H2O (1mg/ml) Molecular Weight: 1209.5 Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight:
1209.5
Purity:
95% (HPLC)
Form:
Supplied as a lyophilized trifluoroacetate salt.
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