PKC Activator VII, CGK062 (Protein Kinase C Activator VII)

Product Overview

• Article Name: PKC Activator VII, CGK062 (Protein Kinase C Activator VII)
• Biozol Catalog Number: USB-217673
• Supplier Catalog Number: 217673
• Alternative Catalog Number: USB-217673-2
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A cell permeable coumarin-containing compound that is shown to activate PKCalpha activity and induce cellular PKCalpha membrane translocation (Effective conc. 12.5 to 50uM) as well as PKCalpha-mediated signaling events. Effectively affects the viability of CRT-dependent cancer cells (IC50 = 1.62 to 18.6uM, 48h) in vitro and suppresses PC3-derived tumor expansion in mice (50 & 100mg/kg/day, i.p) in vivo, while exhibiting little cytotoxicity toward WI38 normal fibroblasts. Molecular Formula: C23H20O7 Primary Target IC50: 12.2uM Solubility: DMSO Molar Mass: 408.4 Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 408.4
• Purity: 98% (HPLC)
• Form: Supplied as an off-white solid.