PKR inhibitor III is a nucleic acid molecule that inhibits PKR. It has been shown to be effective in transfecting cells and has therapeutic potential for use in treating patients with neutrophil disorders. PKR inhibitor III is an oligodeoxynucleotide that contains the sequence of 7-deaza-2-deoxyguanosine (7dG). This sequence is complementary to the anti-sense strand of PKR mRNA and inhibits PKR activity by binding to its mRNA transcript. In vitro studies have shown that this nucleic acid molecule can inhibit PKR activity in tissue samples from patients with neutrophil disorders. Synonyms: 7-Desacetoxy-6,7-dehydrogedunin, Double-stranded RNA-dependent Protein Kinase Inhibitor III, Double-stranded RNA-activated Protein Kinase Inhibitor III, EIF2AK2 Inhibitor III CAS No: 26927-01-5 Molecular Formula: C26H30O5 Molecular Weight: 422.5 Melting Point: 262C Purity (HPLC): 95% 1H-NMR: Conforms to reference Appearance: Pale yellow solid. Storage and Stability: Store at 4C under inert atmosphere. Stable for 6 months after receipt.
Molecular Weight:
422.5
CAS Number:
[26927-01-5]
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