Polo-like Kinase Inhibitor V, Poloxin (2-isopropyl-5-methyl-4-(2-methylbenzoyloxyimino)cyclohexa-2,5-dienone), CAS [[321688-88-4]]

Product Overview

• Article Name: Polo-like Kinase Inhibitor V, Poloxin (2-isopropyl-5-methyl-4-(2-methylbenzoyloxyimino)cyclohexa-2,5-dienone), CAS [[321688-88-4]]
• Biozol Catalog Number: USB-217681
• Supplier Catalog Number: 217681
• Alternative Catalog Number: USB-217681-5
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A thymoquinone derivative, non-ATP competitive Polo-like Kinase 1 (Plk1) inhibitor specifically targeting the polo-box domain (PBD) of Plk1 (IC50)=4.8uM. Reduces both chromosome and kinetochoral localization of Plk1, induces chromosome congression defects , mitotic arrest in prometaphase, and apoptosis in HeLa cells at 25uM. Exhibits anti-proliferative effects in a range of cancer cell lines, and in a mouse Xenograft model involving HeLa and MDA-MB-231 cells at 40mg/kg. CAS Number: 321688-88-4 Formula: C18H19NO3 Molecular Weight: 297.4 Solubility: DMSO (25mg/ml, clear, yellow solution) Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 297.4
• Purity: 99% (HPLC)
• Form: Supplied as a yellow solid.
• CAS Number: [321688-88-4]