PON1 Activator (ZNPA, (Z)-2,3-bis (4-nitrophenyl)-acrylonitrile), CAS [[42172-66-7]]

Product Overview

• Article Name: PON1 Activator (ZNPA, (Z)-2,3-bis (4-nitrophenyl)-acrylonitrile), CAS [[42172-66-7]]
• Biozol Catalog Number: USB-217682
• Supplier Catalog Number: 217682
• Alternative Catalog Number: USB-217682-10
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A cell-permeable stilbene derivative that serves as an aryl hydrocarbon receptor (AhR) and acts as a highly specific and potent inducer of paraoxonase 1 (PON1). Shown to be a better activator of PON1 mRNA (EC50=1uM) and inducer of PON1 enzymatic activity (>3-fold at 5um) when compared to resveratrol. However, it is devoid of any activity against estrogen receptors and is not shown to inhibit activity of tyrosine kinases. Also shown to antagonize the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on cytochrome P4501A1 (CYP1A1). CAS No: 42172-66-7 Formula: C15H9N3O4 Molecular Weight: 295.3 Solubility: DMSO (25mg/ml, pale yellow solution) Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Light Sensitive.

Product Properties

• Molecular Weight: 295.3
• Purity: 99% (HPLC)
• Form: Supplied as a pale yellow solid.
• CAS Number: [42172-66-7]