Porcn Inhibitor II, C59 (Wnt-C59, Wnt Pathway Inhibitor XVI, 2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide), CAS [[1243243-89-1]]

Product Overview

• Article Name: Porcn Inhibitor II, C59 (Wnt-C59, Wnt Pathway Inhibitor XVI, 2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide), CAS [[1243243-89-1]]
• Biozol Catalog Number: USB-217683
• Supplier Catalog Number: 217683
• Alternative Catalog Number: USB-217683-10
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A cell-permeable pyridinylphenyl-acetamide that is much more potent than IWP-2 in inhibiting MBOAT family member Porcupine-mediated Wnt palmitoylation (IC50 = 74 pM in STF reporter assays using Wnt3a-transfected HEK293). Shown to be effective against Porcn of murine and human, but not xenopus, species and potently inhibit the processing of both canonical and non-canonical Wnt subtypes. C59 is demonstrated to be orally active and effectively suppress MMTV-WNT1 tumor expansion in mice (5mg/kg & 10mg/kg p.o.) in vivo. Synonyms: 2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide, Wnt-C59, Wnt Pathway Inhibitor XVI CAS No: 1243243-89-1 Molecular Formula: C25H21N3O Molecular Weight: 379.45 Solubility: DMSO (100mg/ml) Primary Target: Porcupine (Porcn)-mediated Wnt palmitoylation Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 379.45
• Purity: 99% (HPLC)
• Form: Supplied as an off-white powder.
• CAS Number: [1243243-89-1]