PP1 Analog IV, 3-IB-PP1 (3-Iodobenzyl PP1 Analog), CAS [[1174182-24-1]]

Product Overview

• Article Name: PP1 Analog IV, 3-IB-PP1 (3-Iodobenzyl PP1 Analog), CAS [[1174182-24-1]]
• Biozol Catalog Number: USB-217685
• Supplier Catalog Number: 217685
• Alternative Catalog Number: USB-217685-10
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A cell-permeable enlarged PP1 analog that acts as a potent, ATP-competitive and reversible inhibitor of asAkt1/2/3 (IC50=28, 240 and 120nM, respectively) over wtAkt1/2/3 (IC50= >10uM). Shown to hyperphosphorylate Akt-Ser473 and -Thr308 in HEK293 cells coexpressed with myr-HA-asAkt1 or myr-HA-asAkt1/2/3 with no effect on pGSK-3bSer9 levels and wtAkt expressing cells. Also, specifically blocks the inhibitory function of membrane asCsk with diminished activity towards wtCsk, induces phosphorylation of Lck-Tyr394 and ERK1/2 in primary mouse T cells (EC50 ~0.5uM) and rapidly activates T cell receptor signaling. CAS No: 1174182-24-1 Molecular Formula: C16H18IN5 Molecular Weight: 407.3 Appearance: Supplied as a white to yellow solid. Purity: 97% (HPLC) Solubility: DMSO (0.5mg/ml) Storage and Stability: May be stored at 4C. Stable for 6 months after receipt. Reconstitute with DMSO. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Product Properties

• Molecular Weight: 407.3
• Purity: 97% (HPLC)
• Form: Supplied as a white to yellow solid.
• CAS Number: [1174182-24-1]