Protein Methyltransferase Inhibitor II, BIX-01338 (1-(2-(4-(4-Methoxybenzoyloxy)phenyl)ethyl)-2-(4-trifluoromethylbenzoylamino)-1H-benzoimidazole-5-carboxylic Acid, Hydrate, 1-(4-(4-methoxybenzoyloxy)phenethyl)-2-(4-(trifluorometh

Product Overview

• Article Name: Protein Methyltransferase Inhibitor II, BIX-01338 (1-(2-(4-(4-Methoxybenzoyloxy)phenyl)ethyl)-2-(4-trifluoromethylbenzoylamino)-1H-benzoimidazole-5-carboxylic Acid, Hydrate, 1-(4-(4-methoxybenzoyloxy)phenethyl)-2-(4-(trifluorometh
• Biozol Catalog Number: USB-217720
• Supplier Catalog Number: 217720
• Alternative Catalog Number: USB-217720-2
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A cell-permeable amido-benzimidazolo compound that acts as a SAM (S-adenosyl-methionine) competitive, reversible and selective inhibitor of histone lysine/arginine methyltransferases (HKMTases/PRMTases) activity (IC50=1.1, 4.7uM, 6.0 and 10.0uM against SUV39H1(H320R) mutant, G9a, PRMT1 and SET7/9-mediated methylation of H3K9Me2, respectively). Only weakly impairs GLP-catalyzed H3K9Me3 methylation levels (IC50 <40uM). Affects wild-type and G9a deficient mESCs, MEFs and HeLa cell viability without altering their morphology at 15uM. Formula: C32H24F3N3O6 H2O Solubility: DMSO Molecular Weight: 621.6 Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 621.6
• Purity: ~97% (HPLC)
• Form: Supplied as an off-white powder.