A cell-permeable NSC23766 analog that is more selective against Rac interaction with Vav2 (by 45% blockage at 4uM) than Tiam (35% blockage at 50uM) and ~100-times more potent than NSC23766 in suppressing Rac1-GTP level in MDA-MB-435 (IC50=1.1 vs. 95uM, respectively) cultures. Effectively inhibits PAK Thr423 phosphorylation (IC50 <2uM), while reducing Cdc42-GTP level only at higher concentrations (by 18% at 5uM), in MDA-MB-435 cultures. Rac Inhibitor III, EHop-016, CAS 1380432-32-5, is a cell-permeable analog of NSC23766. It is ~100-fold more potent than NSC23766 in suppressing Rac1-GTP level in MDA-MB-435 cells. Synonyms: N4-(9-Ethyl-9H-carbazol-3-yl)-N-(3-morpholin-4-yl-propyl)-pyrimidine-2,4-diamine CAS No: 1380432-32-5 Molecular Formula: C25H30N6O Solubility: DMSO Molecular Weight: 430.6 Purity: 96% (HPLC) Appearance: Pale yellow powder Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight:
430.6
Purity:
96% (HPLC)
Form:
Pale yellow powder
CAS Number:
[1380432-32-5]
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