A blood-brain-barrier-permeant, non-toxic, tertiary amide compound that acts as a high affinity, potent, multimodal blocker of RAGE (Receptor for Advanced Glycation End products) V domain-mediated ligand binding (Ki = 25, 148, and 230nM, respectively, against Ab40, HMGB1, and S100B, binding to sRAGE). Blocks RAGE-mediated influx of Ab40 and Ab42 into the brain. Also shown to suppress Ab-RAGE induced NF-kB activation and NF-kB-dependent transcription of b-secretase. Daily treatment of APPsw/0 murine AD model (1mg/kg/d via i.p.) is reported to greatly reduce Thioflavin S-positive amyloid plaques in cortex and hippocampus (by 70 to 80%) and restore congnitive performance to the level of non-AD mice. CAS No: 945714-67-0 Synonyms: N-Benzyl-4-chloro-N-cyclohexylbenzamide, Receptor for AGE Antagonist, FPS-ZM1 Molecular Formula: C20H22ClNO Molecular Weight: 327.9 Appearance: White to off-white semi-solid or viscous liquid Purity: 98% (HPLC) Solubility: DMF: 30mg/ml, DMF:PBS (pH 7.2), (1:7): 0.12mg/ml, DMSO: 25mg/ml, Ethanol: 15mg/ml Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight:
327.9
Purity:
98% (HPLC)
Form:
White to off-white semi-solid or viscous liquid
CAS Number:
[945714-67-0]
* VAT and and shipping costs not included. Errors and price changes excepted
