Rho/SRF Pathway Inhibitor, CCG-1423 (N-(2-(4-Chloroanilino)-1-methyl-2-oxoethoxy)-3,5-bis(trifluoromethyl)benzamide), CAS [[285986-88-1]]

Product Overview

• Article Name: Rho/SRF Pathway Inhibitor, CCG-1423 (N-(2-(4-Chloroanilino)-1-methyl-2-oxoethoxy)-3,5-bis(trifluoromethyl)benzamide), CAS [[285986-88-1]]
• Biozol Catalog Number: USB-217746
• Supplier Catalog Number: 217746
• Alternative Catalog Number: USB-217746-25
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A cell-permeable benzamide compound that acts as an effective inhibitor against RhoA- and RhoC-mediated cellular activities by targeting signaling events downstream of Ga12/13 and RhoA/C, affecting MKL recruitment and/or postrecruitment function of MKL1, but not SRF-SRE interaction or ROCK kinase activity. CCG-1423 is shown to inhibit RhoC-dependent cell growth in A375M2 and SK-Mel-147 (IC50300nM) and block RhoC/ Ga12-mediated PC-13 invasion in Matrigel assays (by ~90% at 3uM). Synonyms: N-(2-(4-Chloroanilino)-1-methyl-2-oxoethoxy)-3,5-bis(trifluoromethyl)benzamide, MICAL-2 Inhibitor I, MRTF-A/SRF Transcription Inhibitor I, MLK1/SRF Transcription Inhibitor I CAS Number: 285986-88-1 Formula: C18H13ClF6N2O3 Solubility: DMSO (10mg/ml) Molecular Weight: 454.8 Storage and Stability: Store at -20C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Product Properties

• Molecular Weight: 454.8
• Purity: 95% (HPLC)
• Form: Supplied as a white solid.
• CAS Number: [285986-88-1]