A selective 5-HT7 receptor antagonist. Extremely potent in vivo and in vitro. Chronic or acute (even single dose) administration of SB269970 induces functional desensitization of the 5-HT7 receptor system, which precedes changes in the receptor density. This mechanism may be responsible for the rapid antidepressant-like effect of the 5-HT7 antagonist in animal models. SB-269970 is an analogue of SB-258719 and has been shown to have at least 100 fold selectivity versus all other 5-HT receptor subtypes except the human 5-HT5A receptor (pKi values are 8.9, 7.2 and 6.0 for 5-HT7A, 5-HT5A and 5-HT1B). Alternate Names: 5-HT7 Serotonin receptor antagonist, SB-269970, SB 26,970, SB 26,970 CAS Number: 261901-57-9 Form: Supplied as an off-white solid. Purity: ~98% (HPLC) Molecular Formula: C18H28N2O3SHCl Solubility: DMSO Primary Target: 5-HT7 Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Purity:
98% (HPLC)
Form:
Supplied as an off-white solid.
CAS Number:
[261901-57-9]
* VAT and and shipping costs not included. Errors and price changes excepted
