SHIP2 Inhibitor, AS1938909 (3-(2,4-Dichlorobenzyl)oxy]-N-(2,6-difluorobenzyl)thiophene-2-carboxamide, SH2 Domain-containing Inositol 5-phosphatase 2 (SHIP2) Inhibitor)

Product Overview

• Article Name: SHIP2 Inhibitor, AS1938909 (3-(2,4-Dichlorobenzyl)oxy]-N-(2,6-difluorobenzyl)thiophene-2-carboxamide, SH2 Domain-containing Inositol 5-phosphatase 2 (SHIP2) Inhibitor)
• Biozol Catalog Number: USB-217790
• Supplier Catalog Number: 217790
• Alternative Catalog Number: USB-217790-10
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A cell-permeable thiophenecarboxamide compound that is shown to increase glucose metabolism and activate intracellular insulin signaling. Acts as a potent, competitive and reversible inhibitor of SHIP2 activity (Ki=0.44uM for hSHIP2) with moderate to excellent selectivity over SHIP1 and other related phosphatases (IC50=0.18, 0.57, 21, >50, >50 and >50uM for mSHIP2, hSHIP2, hSHIP1, hPTEN, h-synaptojanin and h-myotubularin, respectively). Elevates insulin-induced pAkt-Ser473 levels and enhances glucose transporter GLUT1 mRNA expression in L6 myotubes. SHIP1 Inhibitor, 3AC is also available. Formula: C19H13Cl2F2NO2S Solubility: DMSO Molecular Weight: 371.9 Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 371.9
• Purity: 95% (HPLC)
• Form: Supplied as an off-white solid.