SKP2 E3 Ligase Inhibitor I, C1 (p21/Cip1/Waf1 Activator I, p27/Kip1 Activator I, S-phase Kinase-associated Protein 2 Inhibitor I, SCFSKP2 Inhibitor I, CRL1SKP2 Inhibitor I, (Z)-2-(4-Bromo-2-((4-oxo-3-(pyridin-3-ylmethyl)-2-thioxot

Product Overview

• Article Name: SKP2 E3 Ligase Inhibitor I, C1 (p21/Cip1/Waf1 Activator I, p27/Kip1 Activator I, S-phase Kinase-associated Protein 2 Inhibitor I, SCFSKP2 Inhibitor I, CRL1SKP2 Inhibitor I, (Z)-2-(4-Bromo-2-((4-oxo-3-(pyridin-3-ylmethyl)-2-thioxot
• Biozol Catalog Number: USB-217794
• Supplier Catalog Number: 217794
• Alternative Catalog Number: USB-217794-25
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A cell-permeable rhodanine compound that upregulates cellular p21Cip1/Waf1 and p27Kip1 protein levels (10uM for 16h in 501 Mel cultures) by preventing Skp2-Cks1-mediated substrate recruitment without affecting the F-box E3 ubiquitin ligase Skp2 interaction with Cks1 or the SCF (Skp1-cullin1-F-box) complex. Shown to inhibit the proliferation of human breast cancer MCF-7 and melanoma 501 Mel cells (IC50 = 8 and 30uM, respectively, 16h incubation). Unlike SMIP004, C1 does not affect cellular Cyclin E/CDK2 kinase activity or Skp2 level. Synonyms: p21/Cip1/Waf1 Activator I, p27/Kip1 Activator I, S-phase Kinase-associated Protein 2 Inhibitor I, SCFSKP2 Inhibitor I, CRL1SKP2 Inhibitor I, (Z)-2-(4-Bromo-2-((4-oxo-3-(pyridin-3-ylmethyl)-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetic acid CAS No: 432001-69-9 Molecular Formula: C18H13BrN2O4S2 Solubility: DMSO Primary Target: disrupts p27-Skp2 interaction Molar Mass: 465.3 Purity: 99% (HPLC) Form: Supplied as an orange brown powder. Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at 4C for 6 months after receipt. Light sensitive.

Product Properties

• Molecular Weight: 465.3
• Purity: 99% (HPLC)
• Form: Supplied as an orange brown powder.
• CAS Number: [432001-69-9]