SOD1 Inhibitor, LCS-1 (4,5-dichloro-2-(3-methylphenyl)-3(2H)-pyridazinone, 4,5-dichloro-2-m-tolylpyridazin-3(2H)-one, Superoxide Dismutase 1 Inhibitor, Lung Cancer Screen 1), CAS [[41931-13-9]]

Product Overview

• Article Name: SOD1 Inhibitor, LCS-1 (4,5-dichloro-2-(3-methylphenyl)-3(2H)-pyridazinone, 4,5-dichloro-2-m-tolylpyridazin-3(2H)-one, Superoxide Dismutase 1 Inhibitor, Lung Cancer Screen 1), CAS [[41931-13-9]]
• Biozol Catalog Number: USB-217802
• Supplier Catalog Number: 217802
• Alternative Catalog Number: USB-217802-10
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A 2-phenylpyridazin-3(2H)-one based non-copper chelater that selectively inhibits the activity of Superoxide dismutase 1 (Cu/Zn-SOD) (IC50=1.07uM). Cells over-expressing SOD1 show reduced sensitivity to LCS-1. Shown to preferably inhibit the growth of a variety of human lung adenocarinoma cell lines with EGFR and KRAS mutations (IC50=200nM). Prevents serum-induced activation of the ERK and PI 3-kinase/AKT signaling thereby affecting cell growth and survival. Apparent half-life of this compound is reported to be 6.6min in human liver microsomes. Synonyms: Lung cancer screen 1, 4,5-dichloro-2-m-tolylpyridazin-3(2H)-one, 4,5-dichloro-2-(3-methylphenyl)-3(2H)-pyridazinone, Superoxide dismutase 1 inhibitor CAS Number: 41931-13-9 Formula: C11H8Cl2N2O Solubility: DMSO (50mg/ml, clear, colorless solution) Purity: 99% (HPLC) Form: Supplied as a white solid. Storage and Stability: May be stored at 4C for short-term only. Long-term storage is recommended at -20C. Stable for 1 year after receipt. Protect from light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Product Properties

• Purity: 99% (HPLC)
• Form: Supplied as a white solid.
• CAS Number: [41931-13-9]