Sphingosine Kinase 1 Inhibitor, SKI-178 (N-(1E)-1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide, Dimethoxyphenyl-ethylidene-methoxyphenyl-pyrazole-carbohydrazide)

Product Overview

• Article Name: Sphingosine Kinase 1 Inhibitor, SKI-178 (N-(1E)-1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide, Dimethoxyphenyl-ethylidene-methoxyphenyl-pyrazole-carbohydrazide)
• Biozol Catalog Number: USB-217804
• Supplier Catalog Number: 217804
• Alternative Catalog Number: USB-217804-10
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A cell-permeable pyrazolocarbohydrazide compound that acts as a potent, reversible, sphingosine competitive and ATP-non-competitive inhibitor of sphingosine kinase 1 (SphK1) activity with excellent selectivity over SphK2 (Ki = 1.33 and >> 25uM, respectively). Shown to suppress sphingosine-1-phosphate (S1P) production in A549 cells and efficiently induce apoptosis in several tumor cells (IC50 in the range of 0.1-1.8uM). Synonyms: Dimethoxyphenyl-ethylidene-methoxyphenyl-pyrazole-carbohydrazide, N-(1E)-1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide Molecular Formula: C21H22N4O4 Solubility: DMSO Molar Mass: 394.4 Storage and Stability: Store at 4C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Product Properties

• Molecular Weight: 394.4
• Purity: 92% (HPLC)
• Form: Supplied as an off-white powder.