TGR5 Receptor Agonist, Cpd23g ((4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(4-(2,5-dimethylphenoxy)pyridin-3-yl)methanone, Bile Acid Receptor GPBAR-1 Agonist, Bile Acid Receptor Agonist, G Protein-coupled Bile Acid Receptor 1 Ag

Product Overview

• Article Name: TGR5 Receptor Agonist, Cpd23g ((4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(4-(2,5-dimethylphenoxy)pyridin-3-yl)methanone, Bile Acid Receptor GPBAR-1 Agonist, Bile Acid Receptor Agonist, G Protein-coupled Bile Acid Receptor 1 Ag
• Biozol Catalog Number: USB-217831
• Supplier Catalog Number: 217831
• Alternative Catalog Number: USB-217831-10
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A cell-permeable, orally available, phenoxypyrimidine carboxamide derivative that acts as a highly potent and selective agonist of Protein coupled receptor TGR5 (EC50 = 720 pM and 6.2nM for human and mouse TGR5, respectively). Does not exhibit any significant affinity towards other related targets such as GPR40, GPR119, and GPR120. Shown to increase glucagon-like peptide-1 (GLP-1) secretion in a dose-dependent manner and significantly reduce blood glucose levels in db/db mice following a single oral dose (50mg/kg). Exhibits desirable pharmacokinetic properties in rodent models (t = 1.5h, Cmax = 56ng/ml, and AUC = 147ng.h/ml following an oral dose of 5mg/kg). Solubility: DMSO Primary Target: TGR5 Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Purity: ~98% (HPLC)
• Form: Supplied as a white powder.