Threonine Dehydrogenase Inhibitor, QC1 (N-Benzyl-4-oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroquinazoline-7-carboxamide), CAS [[403718-45-6]]

Product Overview

• Article Name: Threonine Dehydrogenase Inhibitor, QC1 (N-Benzyl-4-oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroquinazoline-7-carboxamide), CAS [[403718-45-6]]
• Biozol Catalog Number: USB-217832
• Supplier Catalog Number: 217832
• Alternative Catalog Number: USB-217832-10
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A cell-permeable quinazolinecarboxamide (QC) compound that acts as a potent, reversible and mixed noncompetitive inhibitor of threonine dehydrogenase activity (IC50 ~ 0.5uM for mTDH) with excellent selectivity over hydroxysteroid, alcohol, lactate, or glucose-6-phosphate dehydrogenases (IC50 >10uM). Shown to block threonine catabolism, induce autophagy and impede the growth of highly proliferating mouse embryonic stem cells (mESCs, EC50 ~3uM) with no effect on ESCs-derived embryoid body cells, 3T3 fibroblasts or tumor cells (EC50 ~1 mM). Synonyms: N-Benzyl-4-oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroquinazoline-7-carboxamide CAS Number: 403718-45-6 Formula: C23H16F3N3O2S Solubility: DMSO Molar Mass: 455.5 Purity: 96% (HPLC) Form: Supplied as a white powder. Storage and Stability: Store at -20C under inert atmosphere. Protect from light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Product Properties

• Molecular Weight: 455.5
• Purity: 96% (HPLC)
• Form: Supplied as a white powder.
• CAS Number: [403718-45-6]