TrkB Antagonist, ANA-12 (N-(2-((2-oxoazepan-3-yl)carbamoyl)phenyl)benzo[b]thiophene-2-carboxamide), CAS [[219766-25-3]]

Product Overview

• Article Name: TrkB Antagonist, ANA-12 (N-(2-((2-oxoazepan-3-yl)carbamoyl)phenyl)benzo[b]thiophene-2-carboxamide), CAS [[219766-25-3]]
• Biozol Catalog Number: USB-217848
• Supplier Catalog Number: 217848
• Alternative Catalog Number: USB-217848-25
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A cell-permeable thiophene carboxymide derived compound that acts as a direct and selective antagonist of TrkB receptor. Binds to the high affinity site on the extracellular domain of TrkB in a dose-dependent manner (Kd = 10nM) exhibiting much reduced binding to the low affinity site (Kd =12uM) indicating that it does not compete with BDNF for the same binding site. Does not affect TrkA or TrkC receptors. Shown to permeate the blood-brain barrier, however, its antagonistic effects are not uniform throughout the brain. Does not affect the survivability of neurons. Reduces anxiety and depression related behavior in mice. CAS Number: 219766-25-3 Molecular Formula: C22H21N3O3S Solubility: DMSO Primary Target: TrkB Primary Target Ki: 10nM Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Purity: 98% (HPLC)
• Form: Supplied as a white solid.
• CAS Number: [219766-25-3]