TRPC3 Channel Inhibitor III, Pyr10 (N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-4-methylbenzenesulfonamide)

Product Overview

• Article Name: TRPC3 Channel Inhibitor III, Pyr10 (N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-4-methylbenzenesulfonamide)
• Biozol Catalog Number: USB-217850
• Supplier Catalog Number: 217850
• Alternative Catalog Number: USB-217850-10
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A cell-permeable pyrazole derivative that acts as a selective blocker of the transient receptor potential cation channel TRPC3-medated ROCE (receptor-operated Ca2+ entry) and inhibits Carbachol-induced Ca2+ entry in TRPC3-expressing HEK293 cells (IC50 = 0.72uM, by Fura-2), while exhibiting much reduced potency against Stim1 and Orai1-coupled CRAC (Ca2+ release-activated Ca2+) channel-mediated SOCE (store-operated Ca2+ entry) in RBL-2H3 cells (IC50 = 13.08uM, by Fura-2). A great complement to Pyr2, Pyr 3, and Pyr6 in Ca2+ signaling studies. Primary Target: TRPC3 Primary Target IC50: 720nM Molar Mass: 449.4 Solubility: DMSO Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 449.4
• Purity: ~98% (HPLC)
• Form: Supplied as an orange brown semi-solid.