Erythromycin displays bacteriostatic activity or inhibits growth of bacteria, especially at higher concentrations,[25] but the mechanism is not fully understood. By binding to the 50s subunit of the bacterial rRNA complex, protein synthesis and subsequent structure and function processes critical for life or replication are inhibited.[25] Erythromycin interferes with aminoacyl translocation, preventing the transfer of the tRNA bound at the A site of the rRNA complex to the P site of the rRNA complex. Without this translocation, the A site remains occupied, thus the addition of an incoming tRNA and its attached amino acid to the nascent polypeptide chain is inhibited. This interferes with the production of functionally useful proteins, which is the basis of this antimicrobial action. Synonyms: E-Base, E-Mycin, Erytromycin A, Aknemycin, Aknin, emgel, Ery-Derm, Erymax, Ery-Tab, Erythromid, ERYC CAS No: 114-07-8 Molecular Formula: C37H67NO13 Molecular Weight: 733.98 Purity: 85.0-100.5% (Dry basis) Appearance: White or almost white crystalline powder Water (Karl Fisher): 10% Optical Rotation: -71 to -78 Residual Solvents: 0.05% (Acetone) 0.05% (n-Butyl acetate) Related Substances: Erythromycin A enol ether: 3% Erythromycin B: 12% Erythromycin C: 5% Any individual impurity: 3% Residue On Ignition: 0.2% Limit of Thiocynate: 0.3% Storage and Stability: Powder is stable for 6 months after receipt at 4C.
Molecular Weight:
733.98
Purity:
85.0-100.5% (Dry basis)
Form:
White or almost white crystalline powder
CAS Number:
[114-07-8]
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