| Tyloxapol is a nonionic liquid polymer of the alkyl aryl polyether alcohol type. It is used as a surfactant to aid liquefaction and removal of mucopurulent[citation needed] (containing mucus and pus) bronchopulmonary secretions administered by inhalation through a nebulizer or with a stream of oxygen. With intraperitoneal injection, tyloxapol also blocks plasma lipolytic activity, and thus the breakdown of triglyceride-rich lipoproteins. This mechanism is used to induce experimental hyperlipidemia in animals. Tyloxapol is the main active ingredient of the medical device Tacholiquin. Tacholiquin is an expectorant designated for inhalation and instillation reaching the upper and lower airways. Synonyms: p-(1,1,3,3-Tetramethylbutyl)Phenol Polymer with Ethylene Oxide and Formaldehyde, Ethylene Oxide Polymer with Formaldehyde and p-(1,1,3,3-Tetramethylbutyl)phenol, Oxirane Polymer with Formaldehyde and 4-(1,1,3,3-tetramethylbutyl)phenol, Ethylene oxide-formaldehyde-4-(1,1,3,3-tetramethylbutyl)phenol copolymer, Ethylene oxide-formaldehyde-p-octylphenol Copolymer, NSC 90255, Superinone, Triton A 20, Triton WR 1339, Tyloxapol, p-Isooctylpolyoxyethylenephenol Formaldehyde Polymer CAS No: 25301-02-4 Molecular Formula: (C17H30O4)n Appearance: Viscous amber liquid, may exhibit slight turbidity Identity (UV): Conforms to structure. Exhibits maximum and minimum at the same wavelengths as RS Identity (IR): Conforms to structure Cloud Point: 92-97C Water (KF): 1% pH: 5-7 Residue On Ignition: 1% Refractive Index (n25D): 1.495 - 1.501 Solubility: Slowly but freely miscible with water. Soluble in glacial Acetic acid, Toluene, and Chloroform. Storage and Stability: Store at 4C. Stable for 6 months after receipt. |
