Selective inhibitor of Akt/PKB. Inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5uM), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Shows no activity at PDK1, SGK1 or PI 3-kinase. Inhibits cell growth (IC50 ~ 2-6uM) and induces apoptosis in rhabdomyosarcoma cells. Synonyms: 10-[4-(N,N-Diethylamino)butyl]-2-chlorophenoxazine hydrochloride CAS Number: 925681-41-0 Molecular Weight: 381.34 Molecular Formula: C20H25N2OCl.HCl Method for Determining Identity: Proton NMR Spectroscopic and Mass Spectrometric Analysis TLC: Rf = 0.53 (Chloroform:Methanol:Ammonia soln. [90:9:1]) Solubility: Soluble to 100mM in water and to 100mM in DMSO Appearance: Supplied as an off-white solid. Purity: 99% (HPLC) Storage and Stability: Store at 4C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
381.34
Purity:
99% (HPLC)
Form:
Supplied as an off-white solid.
CAS Number:
[925681-41-0]
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