Competitive P2X7 receptor antagonist (pIC50 = 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line). Devoid of activity at other P2 receptors (IC50 >> 10 µM). Possesses antinociceptive activity in models of neuropathic pain in vivo. Inhibits methamphetamine-induced microglial migration and phagocytosis in vitro. Alternate Name: 3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine Monohydrochloride, 3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine Monohydrochloride, A 438079 CAS Number: 899431-18-6 Molecular Formula: C13H10Cl3N5 Molecular Weight: 342.61 Purity: 98% (HPLC)
Molecular Weight:
342.61
Purity:
98% (HPLC
CAS Number:
[899431-18-6]
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