Potent inhibitor of protein kinase D (PKD), inhibits all PKD isoforms (IC50 values are 1, 2 and 2.5nM for PKD1, PKD3 and PKD2 respectively). Exhibits selectivity for PKD against a panel of >90 protein kinases, including PKC-alpha, MEK, ERK, c-Raf and c- Src. Reduces proliferation and cell viability of pancreatic cancer cells expressing moderate levels of endogenous PKD1/2. Orally bioavailable. Appearance: Yellow solid Purity: 98% Solubility: Soluble in water to 20mM and soluble in DMSO to 10mM Method for Determining Identity: Proton NMR and MS Elemental Analysis: Calculated: 50.35% C, 6.1% H, 19.57% N Found: As reported Storage and Stability: Store at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
411.33
Purity:
98%
Form:
Yellow solid
CAS Number:
[1883545-60-5]
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