Cucurbitacin I is a selective inhibitor of STAT3/JAK2 signaling. Inhibits the activation of STAT3 and JAK2 and displays no activity on Src, Akt, ERK and JNK. Suppresses phosphotyrosine levels of STAT3, inhibits STAT3 DNA binding and STAT3-mediated gene expression. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3. Synonyms: (9beta,10alpha,16alpha,23E)-2,16,20,25-Tetrahydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione, Elatericin B,JSI 124 CAS No: 2222-07-3 Molecular Formula: C30H42O7 Molecular Weight: 514.65 Appearance: White solid Purity: 95% Solubility: DMSO: 10mM, Chloroform, Dichloromethane, Ethyl Acetate, Acetone Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
514.65
Purity:
95%
Form:
White solid
CAS Number:
[2222-07-3]
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