Erastin is a selective antitumor agent that displays greater lethality in human tumor cells harboring mutations in the oncogenes HRAS, KRAS or BRAF. It binds to mitochondrial volatage-dependent anion channels (VDAC) proteins, more specifically on VDAC2 and alters its gating. Erastin rapidly induces an oxidative, non-apoptotic cell death in several human tumors harboring activating mutations in the RAS-RAF-MEK signaling. Synonyms: 2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone CAS No: 571203-78-6 Molecular Formula: C30H31ClN4O4 Molecular Weight: 547.04 Appearance: Supplied as a white solid Purity: 98% Melting Point: 173-177C Solubility: Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly) Method for Determing Identity: Proton NMR (DMSO-d6, CDCl3) and Mass Spectrometric Analysis TLC Conditions: SiO2, Ethyl Acetate: Hexane=9:1, Visualized with UV and AMCS, Single Spot, Rf=0.55 Elemental Analysis: Calculated: %C: 65.87, %H: 5.71, %N: 10.24 Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at 4C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
547.04
Purity:
98%
Form:
Supplied as a white solid
CAS Number:
[571203-78-6]
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