H 89 dihydrochloride is a protein kinase A inhibitor that also inhibits several other kinases (IC50 values are 80, 120, 135, 270, 2600 and 2800nM for S6K1, MSK1, PKA, ROCKII, PKBalpha and MAPKAP-K1b). Exhibits antinociceptive activity. Enhances survival and clonogenicity of dissociated human ESCs through ROCK inhibition. Synonyms: N-[2-[[3-(4-Bromophenyl)-2-propen-1-yl]amino]ethyl]-5-isoquinolinesulfonamide Hydrochloride, H-89 Dihydrochloride CAS No: 130964-39-5 Free Base: 127243-85-0 Molecular Formula: C20H22BrCl2N3O2S Molecular Weight: 519.28 Purity: 98% Appearance: White to off-white solid Melting Point: 195-200C (lit) Solubility: Soluble to 25mM in water and to 100mM in DMSO Method for Determining identity: Proton NMR and Liquid Chromatography-Mass Spectrometry Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C for 6 months after receipt.
Molecular Weight:
519.28
CAS Number:
[130964-39-5]
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