MKT-077 is used in the treatment of Alzheimers diseases and other tauopathies. Also, is a rhodacyanine derivative that selectively targets cancer cells and overcomes tamoxifen resistance. Binds mot-2, selectively cytotoxic in cancer cells. Biological Activity: Occupies mortalin-2 (mot-2), a member of the Hsp70 family, at its p53 binding site and enables p53 translocation to the nucleus. Selectively cytotoxic, causes growth arrest of cancer cells in culture. Also inhibits telomerase activity and cross-links F-actin. Synonyms: 1-Ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium Chloride, FJ 776 CAS No: 147366-41-4 Molecular Formula: C21H22N3OS2 Ci Molecular Weight: 441.01 Appearance: Orange-red solid Purity: 98% 1H NMR: Consistent with structure Mass Spectrum: Consistent with structure Microanalysis: Carbon Hydrogen Nitrogen Theoretical 57.19 5.26 9.53 Found 56.93 5.31 9.44 Solubility: Soluble to 50mM in water and to 50mM in DMSO Storage and Stability: Store at 4C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
441.01
Purity:
98% (HPLC)
Form:
Orange-red solid
CAS Number:
[147366-41-4]
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